Xenobiotics in the humain body

the xenobiotic in the body pass by 5 steps, summarized in four or five letters: "ADME" or "ADMET" - thelast measurement, toxicity, being sought systematically in certain
Preclinical studies (eg bradypnea / apnea after intravenous administration of morphin)
• "A" for absorption (absorption / penetration in the body);
• "D" for Distribution (dissemination);
• "M" for metabolism (biotransformation);
• "E" for disposal;
• "T" for toxicity (when it can directly determine a limiting effect
dependent on the concentration in the central compartment). illustrates the fate of a drug in the body.

We describe the stages of absorption, distribution and disposal require the crossing of physiological barriers by the xenobiotic.Books and more specialized sites will find more aspects